abstract：:Biological methods are widely used in the treatment of intestinal inflammation (II). The TNFalpha inhibitor infliximab can quickly correct recurrence, provide long-term remission and reduce hormone need in many patients with hormone-resistant and hormone-dependent forms of Crohn's disease (CD) and ulcerative colitis (...

journal_title：Terapevticheskii arkhiv

authors： Lazebnik LB

更新日期：2011-01-01 00:00:00

abstract：:Calcitriol is important in nephroprotective strategy in chronic disease of the kidneys (CDK). However, its long-term use often results in hypercalciemia with metastatic calcification. Compared to calcitriol, paricalcitol (zemplar)--metabolite of vitamin D2--leads to hypercalciemia less frequently, has a more potent ne...

journal_title：Terapevticheskii arkhiv

authors： Milovanov IuS,Kozlovskaia LV,Milovanova LIu

更新日期：2011-01-01 00:00:00

abstract：AIM:To evaluate severity of nephrinuria (NU) as a marker of podocyte dysfunction (PD) in patients with proteinuric forms of chronic glomerulonephritis (CGN) and to specify efficacy of this test for assessment of activity and prognosis of CGN. MATERIAL AND METHODS:We examined 74 CGN patients: 18 with inactive nephritis...

journal_title：Terapevticheskii arkhiv

authors： Chebotareva NV,Bobkova IN,Kozlovskaia LV,Tsopanova ZG

更新日期：2011-01-01 00:00:00

abstract：:Antiplatelet drugs are essential in current treatment of coronary heart disease (CHD) but they have an adverse action--damage to gastrointestinal mucosa. Long-term administration of several medicines in CHD patients makes possible interaction of some drugs. Clinical trials show that proton pump inhibitors (PPI) reduce...

journal_title：Terapevticheskii arkhiv

authors：

更新日期：2011-01-01 00:00:00

abstract：AIM:To study levels of hepsidine (Hp), hypoxia-inducible factor-1alpha (HIF-1alpha), erythropoietin (EP) and ferritin in patients with acute leukemia (AL), effects of protein fractions of homogenate of blastic cells (BC) on regulatory proteins studied. MATERIAL AND METHODS:Depending on leukocyte count in the onset of ...

journal_title：Terapevticheskii arkhiv

authors：

更新日期：2011-01-01 00:00:00

abstract：:Recent revolution in the knowledge about structure, physiological and pathophysiological effects of renin-angiotensin-aldosteron system (RAAS) took place recently when it was discovered that local synthesis of all the RAAS components occurs in target organs and their tissues (the heart, kidneys, vessels, brain tissues...

journal_title：Terapevticheskii arkhiv

authors： Shestakova MV

更新日期：2011-01-01 00:00:00

abstract：AIM:To demonstrate great importance of intravital morphological examination of the liver for differential diagnosis of chronic diffuse diseases (CDD) of the liver. MATERIAL AND METHODS:A complete clinical examination, needle or intraoperative biopsy of the liver were made in 1045 patients with chronic diseases of the ...

journal_title：Terapevticheskii arkhiv

authors： Khomeriki SG,Iakhimchuk GN,Golovanova EV

更新日期：2011-01-01 00:00:00

abstract：:The article is devoted to a rare congenital heart disease--corrected transposition of the major vessels. A hemodynamic scheme of the disease, its probable prognosis, possible development of arrhythmia, impairment of conduction and cardiac failure are described. A case is reported of myocardial infarction of anatomical...

journal_title：Terapevticheskii arkhiv

authors：

更新日期：2011-01-01 00:00:00

abstract：:The article deals with current studies on the role of uric acid (UA) in development of cardiovascular diseases. The results of large prospective trials are presented which have revealed a pathogenetic role of UA in development of essential hypertension. Clinical trials demonstrated elevated concentrations of UA in hyp...

journal_title：Terapevticheskii arkhiv

authors： Polovitkina OV,Oshchepkova EV,Dmitriev VA,Titov VN

更新日期：2011-01-01 00:00:00

abstract：AIM:To study morphoimmunological and clinical features of primary mediastinal large B-cell lymphoma (PMLBCL). MATERIAL AND METHODS:We analysed the results of biopsy material study and treatment of 86 PMLBCL patients, effects of different factors on the disease prognosis, efficacy of some therapeutic programs and overa...

journal_title：Terapevticheskii arkhiv

authors： Kichigina MIu,Tumian GS,Kovrigina AM,Trofimova OP,Larionova VB,Chekan AA,Bykov DA,Osmanov DSh

更新日期：2011-01-01 00:00:00

abstract：:Wide clinical application of modern prophylactic, diagnostic and therapeutic methods has significantly improved clinical outcomes of cardiovascular disorders. However, much progress is not seen in survival of patients with chronic cardiac failure (CCF). Three possible causes of this situation are analysed: absence of ...

journal_title：Terapevticheskii arkhiv

authors： Tereshchenko SN,Zhirov IV

更新日期：2011-01-01 00:00:00

abstract：AIM:To ascertain whether high arterial rigidity is obligatory in arterial hypertension (AH) and the presence of AH is obligatory in patients with rigid arteries. MATERIAL AND METHODS:Volume sphygmography (VS) was made in 153 patients aged 60-86 years: 96 patients with untreated AH of degree 1-3 (40 males aged 71.0 +/-...

journal_title：Terapevticheskii arkhiv

authors： Boĭtsov SA,Rogoza AN,Kanishcheva E,Luk'ianov MM

更新日期：2011-01-01 00:00:00

abstract：AIM:To assess efficacy of two- and three-component antihypertensive treatment (AHT) in patients with severe sleep apnea and arterial hypertension (AH) of the second and third degree in combination with CPAP therapy (continuous positive air pressure) and without it. MATERIAL AND METHODS:A total of 58 patients aged 55.5...

journal_title：Terapevticheskii arkhiv

authors： Sukmarova ZN,Litvin AIu,Chazova IE,Rogoza AN

更新日期：2011-01-01 00:00:00

abstract：AIM:To study effects of methotrexate on the titer of antibodies to mutated citrullinated vimentin (anti-MCV) and ascertain possibility of using this marker for control of treatment results and choice of individual effective dose of the drug. MATERIAL AND METHODS:A 12-month trial included 76 patients with verified rheu...

journal_title：Terapevticheskii arkhiv

authors： Shilkina NP,Voronina MS,Vinogradov AA,Borisova OL

更新日期：2011-01-01 00:00:00

abstract：:Renal damage in HIV infection may result from direct action of HIV and from other causes including nephrotoxic action of medicines. HIV-infected patients receive a wide spectrum of medicines and can be placed in a risk group of drug-induced damage to the kidneys. Risk of nephrotoxicity should be considered in administ...

journal_title：Terapevticheskii arkhiv

authors： Iushchuk ND,Volgina GV,Tomilina NA,Gadzhikulieva MM

更新日期：2011-01-01 00:00:00

abstract：AIM:To analyse lethal outcomes in patients with newly-diagnosed respiratory tuberculosis comorbid with HIV-infection depending on initial count of CD4+ lymphocytes. MATERIAL AND METHODS:Of 304 HIV patients with newly-diagnosed tuberculosis treated in Moscow Tubercusis Hospital N 7 in 2006-2010, 40 (13.2%) patients die...

journal_title：Terapevticheskii arkhiv

authors： Zimina VN,Kravchenko AV,Ziuzia IuR,Batyrov FA,Popova AA,Klimov GV,Parkhomenko IuG,Vasil'eva IA

更新日期：2011-01-01 00:00:00

abstract：AIM:To estimate the distribution of HLA Class I (A, B) antigens in patients with Behcet's disease (BD) and the association of HLA-B5 antigen with the clinical manifestations of the disease in different ethnic and population groups in relation to gender. SUBJECTS AND METHODS:The study covered 93 patients (68 males, 25 ...

journal_title：Terapevticheskii arkhiv

authors： Goloeva RG,Alekberova ZS,Guseva IA,Krylov MIu

更新日期：2010-01-01 00:00:00

abstract：AIM:to evaluate brachial artery (BA) endothelial vasomotor function in patients with systemic lupus erythematosus (SLE) and scleroderma systematica (SDS), by using noninvasive studies. Subjects and methods. Sixty-five patients, including 25 with SLE, 20 with SDS, and 20 with atherosclerosis (AS) obliterans of lower ext...

journal_title：Terapevticheskii arkhiv

authors： Vinogradov AA,Shilkina NP,Kostyreva NA

更新日期：2010-01-01 00:00:00

abstract：:The paper emphasizes a role of a local therapist in the timely detection and treatment of acute respiratory viral infections. It shows a certain difficulty in the differential diagnosis of acute respiratory disease and influenza. Attention is given on a need for a well-defined program to correct drug therapy, regimen,...

journal_title：Terapevticheskii arkhiv

authors： Galkin VA

更新日期：2010-01-01 00:00:00

abstract：AIM:to characterize the markers of endothelial dysfunction and the effect of antihypertensive drugs on them in patients with chronic urate tubulointestinal nephritis (UTIN) and articular gout. SUBJECTS AND METHODS:The study enrolled 81 patients aged 39 to 59 years with gout and urate nephropathy. All the patients were...

journal_title：Terapevticheskii arkhiv

authors： Lebedeva MV,Stakhova TIu,Zaĭtseva LI,Selivanova OIu,Severova MM

更新日期：2010-01-01 00:00:00

abstract：AIM:To study left ventricular structural and functional changes in patients with chronic obstructive pulmonary disease (COPD) and chronic cor pulmonale (CCP) at different stages of a cardiac remodeling process. SUBJECTS AND METHODS:Echocardiography was used to examine 98 patients with COPD complicated by the developme...

journal_title：Terapevticheskii arkhiv

authors： Strutynskiĭ AV,Bakaev RG,Glazunov AB,Banzeliuk EN,Moshkova NK,Reĭsner AA,Shavurdina SV,Vinogradova DV

更新日期：2010-01-01 00:00:00

abstract：:The paper presents a case history of multiple myeloma in a female patient. Its diagnosis was established only 10 years after the onset of the disease, which results in severe invalidity (she was treated with calcium preparations in accordance with the diagnosis of generalized osteoporosis. Persistent therapy with calc...

journal_title：Terapevticheskii arkhiv

authors： Polishchuk PR,Petrenko LI,Kriuchkov MI,Morozov SP,Brodetskiĭ BM

更新日期：2010-01-01 00:00:00

abstract：AIM:To study markers of myocardial electrical instability in patients with coronary heart disease (CHD) during silent myocardial ischemic episodes. SUBJECTS AND METHODS:Eighty-two patients with stable CHD (mean age 62.6 +/- 5.4 years) were examined. In addition to standard physical examination, a complex of their stud...

journal_title：Terapevticheskii arkhiv

authors： Tatarchenko IP,Pozdniakova NV,Morozova OI,Zaĭtseva AV

更新日期：2010-01-01 00:00:00

abstract：AIM:To study the survival and sequestration of transfused donor platelets labeled with 51Cr in patients with acute leukemia (AL). SUBJECTS AND METHODS:Seven donor volunteers and 39 patients with different forms with AL at various stages of polychemotherapy (PCT) were examined. Cytostatic therapy was accompanied by 51C...

journal_title：Terapevticheskii arkhiv

authors： Migunova EV,Sakhibov IaD,Ryzhko VV,Sorokina OM,Sagdieva NSh,Gemdzhian EG

更新日期：2010-01-01 00:00:00

abstract：:Fundamental innovations in the study of the regulatory mechanisms of circulation in the past 20-30 years (evidence for the role of the endothelium in local hemodynamic control, the basic significance of the tissue link of the angiotensin mechanism (A-II) of not only as a vasoconstrictor, but also a trigger of a slow p...

journal_title：Terapevticheskii arkhiv

authors： Gogin EE

更新日期：2010-01-01 00:00:00

abstract：:The use of imatinib mesylate (Glivec) (Novartis Pharma AG, Switzerland) that is the drug of choice in treating patients with chronic myeloid leukemia (CML) has increased 7-year survival and improved the prognosis of the disease. The drug is generally tolerated well; the proportion of patients in whom imatinib treatmen...

journal_title：Terapevticheskii arkhiv

authors： Stakhina OV,Turkina AG,Kostina IE,Kochkareva IuB

更新日期：2010-01-01 00:00:00

abstract：AIM:to study the time course of changes in the gastric juice levels of nitric oxide (NO) in patients with esophagogastroduonenal diseases (EGDD). SUBJECTS AND METHODS:One hundred and seventy-four patients with EGDD were examined. RESULTS:In patients with chronic atrophic gastritis, the level of NO was significantly l...

journal_title：Terapevticheskii arkhiv

authors： Esedov EM,Magomedeminova AS

更新日期：2010-01-01 00:00:00

abstract：:The results of a study of the efficiency of treatment in patients with chronic hepatitis C conducted in a complex of multicenter clinical trials of the impact of various antiviral therapy regimens including the interferon genesis inductor cycloferon are reviewed. Four hundred and seventy-eight patients with hepatitis ...

journal_title：Terapevticheskii arkhiv

authors： Sologub TV,Romantsev MG,Shul'diakov AA,Lin'kova IuN,Radchenko VG,Kovalenko AL

更新日期：2010-01-01 00:00:00

abstract：AIM:to study the prevalence, pattern of and trends in affective disorders (AD) in patients with acute myocardial infarction (AMI) and to assess whether they might be corrected with the antidepressant tianeptin. SUBJECTS AND METHODS:The study enrolled 108 patients with AMI. To detect and evaluate affective spectrum dis...

journal_title：Terapevticheskii arkhiv

authors： Vasiuk IuA,Lebedev AV,Dovzhenko TV,Semiglazova MV

更新日期：2010-01-01 00:00:00

abstract：AIM:To study the time course of changes in the activity of the protein C system and other hemostatic parameters under intravascular laser irradiation of blood (ILIB) in patients with community-acquired pneumonia (CAP). SUBJECTS AND METHODS:One hundred and forty patients aged 17 to 62 years (mean 39.5 +/- 8.4 years) wi...

journal_title：Terapevticheskii arkhiv

authors： Burduli NM,Pilieva NG

更新日期：2010-01-01 00:00:00

abstract：AIM:to evaluate the efficacy of cyclopheron used in patients with mild clinical manifestations of focal and infiltrative pulmonary tuberculosis (PT). SUBJECTS AND METHODS:Thirty first detected patients with PT, in whom a complex of their etiotropic therapy comprised cyclopheron, and 32 similar patients who received et...

journal_title：Terapevticheskii arkhiv

authors： Filippova TP,Vasil'eva LS,Kochkin AV

更新日期：2010-01-01 00:00:00

abstract：:The paper reviews the main problems of vaccine prophylaxis of adult infectious diseases, including the organization of adult vaccination within the national calendar of immunization and that as indicated by epidemics. It gives data on vaccine-controlled adult infectious morbidity. The problems of the training of medic...

journal_title：Terapevticheskii arkhiv

authors： Pokrovskiĭ VI,Mikheeva IV

更新日期：2010-01-01 00:00:00

abstract：:In Russia, diabetes mellitus afflicts 8 million people, 90% of them had type 2 diabetes mellitus (T2DM) and this figure is growing steadily. At the same time there is a rise in the incidence of macrovascular events (unstable angina pectoris, myocardial infarction). Coronary heart disease and its attack are a major cau...

journal_title：Terapevticheskii arkhiv

authors： Ametov AS,P'ianykh OP,Chernikova NA

更新日期：2010-01-01 00:00:00

abstract：AIM:to assess the long-term angiographic and clinical results of percutaneous coronary interventions (PCI) with implantation of the drug-eluting stent (DES) Apollo in patients with stable angina pectoris. SUBJECTS AND METHODS:The study enrolled 48 patients with stable angina who had been implanted with 59 stents. A fo...

journal_title：Terapevticheskii arkhiv

authors： Batyraliev TA,Fettser DV,Samko AN,Sidorenko BA

更新日期：2010-01-01 00:00:00

abstract：AIM:To characterize a superficial phenotype and to make a cytogenetic analysis of bone marrow (BM) mesenchymal stromal cells (MSC) from donors. MATERIALS AND METHODS:The study analyzed BM samples from 11 healthy donors. The phenotype of obtained MSC was analyzed using cytofluorometry. Chromosomal analysis was carried ...

journal_title：Terapevticheskii arkhiv

authors： Svinareva DA,Shipunova IN,Ol'shanskaia IuV,Momotiuk KS,Drize NI,Savchenko VG

更新日期：2010-01-01 00:00:00

abstract：AIM:To evaluate the effect of ACE inhibitor enalapril, AR blocker candesartan and their combination on left ventricular hypertrophy (LVH) and content of biochemical markers of collagen balance in patients with hypertensive LV hypertrophy. MATERIAL AND METHODS. A total of 66 patients with arterial hypertension with LV h...

journal_title：Terapevticheskii arkhiv

authors： Ovchinnikov AG,Serbul VM,Ageev FT

更新日期：2009-01-01 00:00:00

abstract：AIM:To study immune disorders in cell immunity and cytokine profile in integument lupus erythematosus (ILE) and systemic lupus erythematosus (SLE). MATERIAL AND METHODS:Lymphocyte phenotype, oxygen-dependent and non-oxygen-dependent functions of circulating neutrophils and monocytes, serum levels of circulating immune...

journal_title：Terapevticheskii arkhiv

authors： Romanova NV,Shilkina NP

更新日期：2009-01-01 00:00:00

abstract：AIM:To investigate the effects of coronary stenting with rapamycin-eluting stents on parameters of cell immunity. METHODS:26 patients (group 1) with stable coronary heart disease and angiographically proved coronary stenosis underwent stenting with rapamycin-eluting stents. The control group (group 2) consisted of 6 p...

journal_title：Terapevticheskii arkhiv

authors： Aref'eva TI,Provatorov SI,Potekhina AV,Sokolov VO,Kukhtina NB,Samko AN,Krasnikova TL

更新日期：2009-01-01 00:00:00

abstract：AIM:To assess an effect of long-term administration of one combined inhaled drug containing glucocorticosteroids (GCS) and long-acting beta2-agonists (LABA) on patient compliance. MATERIAL AND METHODS:The trial included 47 patients (14 males and 33 females, mean age 48.8 +/- 13.2 years) with bronchial asthma (BA) of d...

journal_title：Terapevticheskii arkhiv

authors： Ovcharenko SI,Akulova MN

更新日期：2009-01-01 00:00:00

abstract：:New evidence is reviewed on efficacy and safety of chimeric monoclonal antibodies to B-cell CD20 molecule (rituximab) in the treatment of rheumatoid arthritis. ...

journal_title：Terapevticheskii arkhiv

authors： Nasonov EL

更新日期：2009-01-01 00:00:00